NMDA receptors sustain but do not initiate neuronal depolarization in spreading depolarization
نویسندگان
چکیده
منابع مشابه
Mechanisms of Neuronal Swelling during Spreading Depolarization
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متن کاملTransient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression.
Cortical spreading depression (SD) is a propagating wave of neuronal and glial depolarization that manifests in several brain disorders. However, the relative contribution of neurons and astrocytes to SD genesis has remained controversial. This is in part due to a lack of utilizing sophisticated experimental methodologies simultaneously to quantify multiple cellular parameters. To address this,...
متن کاملIschemia-induced spreading depolarization in the retina.
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now ...
متن کاملSpreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
Spreading depolarization of cells in cerebral grey matter is characterized by massive ion translocation, neuronal swelling and large changes in direct current-coupled voltage recording. The near-complete sustained depolarization above the inactivation threshold for action potential generating channels initiates spreading depression of brain activity. In contrast, epileptic seizures show modest ...
متن کاملMitochondrial depolarization is not required for neuronal apoptosis.
Mitochondria are sites of cellular energy production but may also influence life and death decisions by initiating or inhibiting cell death. Mitochondrial depolarization and the subsequent release of pro-apoptotic factors have been suggested to be required for the activation of a cell death program in some forms of neuronal apoptosis. We induced apoptosis in cultured rat hippocampal neurons by ...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2020
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2020.105071